Peter Quill, still reeling from the loss of Gamora, must rally his team around him to defend the universe along with protecting one of their own. A mission that, if not completed successfully, could quite possibly lead to the end of the Guardians as we know them.
Peter Quill masih terhuyung-huyung trauma karena kehilangan Gamora. Ia perlu mengumpulkan timnya di sekelilingnya untuk mempertahankan alam semesta dan melindungi salah satu anggota mereka. Jika mereka gagal, Guardian akan berakhir.